| Bioactivity | TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 9 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 97%[1]. |
| CAS | 3034750-61-0 |
| Formula | C38H43N7O8 |
| Molar Mass | 725.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang W, et al., Benzazepine derivative, conjugate containing same, and use thereof. WO2024067841A1. |
TLR8 agonist 9
CAS: 3034750-61-0 F: C38H43N7O8 W: 725.79
TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is
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