| Bioactivity | XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer[1]. |
| Invitro | Xl 188 (1-20 μm; 16 h; MCF7 细胞) 促进 USP7 依赖性 HDM2 的丢失和 p53 和 p21 的增加[1]。 Western Blot Analysis[1] Cell Line: |
| Name | XL 188 |
| CAS | 2305045-76-3 |
| Formula | C32H42N6O4 |
| Molar Mass | 574.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Stolte B, et, al. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 Aug 6;215(8):2137-2155. |