| Bioactivity | Wnt/β-catenin-IN-5 (Compound 4) is an inhibitor of the Wnt/β-catenin signaling pathway. Wnt/β-catenin-IN-5 can eliminate colorectal cancer stem cells and inhibit tumor growth by suppressing the Wnt signaling pathway. Additionally, Wnt/β-catenin-IN-5 effectively induces the degradation of KDM3A and KDM3B[1]. |
| Formula | C33H37N5O10 |
| Molar Mass | 663.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zaman S U, et al. Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling[J]. RSC Medicinal Chemistry, 2024. |