| Bioactivity | Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors[1]. |
| Invitro | Wnt/β-catenin-IN-1 (compounds 17) (10 μM，48 h) 具有广谱抗癌活性，对试验中的 52 个肿瘤细胞系平均生长抑制率为 81.9%[1]。Wnt/β-catenin-IN-1 (compounds 17) (10 μM，48 h) 对于对正常人类细胞系 (CCD841, MRC5) 的细胞毒性作用较低，对癌细胞具有一定的选择性[1]。Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM，24 h/48 h) 剂量依赖性地触发细胞周期阻滞，增加了 G2/M 细胞周期期 HCT116 结肠癌细胞的数量[1]。Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM，24 h) 使 HCT 结直肠癌细胞中的 CDK8 水平呈剂量依赖性降低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Wnt/β-catenin-IN-1 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C26H25NO7 |
| Molar Mass | 463.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hassan AHE, et al. Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/β-catenin signaling pathway inhibitor. Bioorg Chem. 2024 Feb 5;145:107178. |