| Bioactivity | Waglerin-1, a 22-amino acid peptide, is a competitive antagonist of the muscle nicotinic receptor (nAChR)[1]. |
| Target | nAChR |
| Name | Waglerin-1 |
| CAS | 145038-84-2 |
| Sequence | Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys-His-Pro-Pro-Cys-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg (Disulfide bridge: Cys9-Cys13) |
| Shortening | GGKPDLRPCHPPCHYIPRPKPR (Disulfide bridge: Cys9-Cys13) |
| Formula | C112H175N37O26S2 |
| Molar Mass | 2519.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Brian E Molles, et al. Identification of Residues at the α and ε Subunit Interfaces Mediating Species Selectivity of Waglerin-1 for Nicotinic Acetylcholine Receptors. J Biol Chem. 2002 Feb 15;277(7):5433-40. [2]. J H Ye, et al. Waglerin-1 inhibits GABAA current of neurons in the nucleus accumbens of neonatal rats. Brain Res. 1999 Aug 7;837(1-2):29-37. |