| Bioactivity | WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect[1]. |
| Invitro | WSD0628 significantly increased the radiosensitivity of U251 cells in clonogenic survival assays (0 nM vs. 30 nM at 5Gy, p 0 --> WSD0628 相关抗体: |
| In Vivo | WSD0628 (10 mg/kg, a single dose of 12.5 Gy combined) has profound impact on treatment efficacy in the melanoma brain metastasis M12 PDX[1]. |
| Name | WSD0628 |
| CAS | 2765448-96-0 |
| Formula | C23H23F2N5O2 |
| Molar Mass | 439.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhiyi Xue, et al. Abstract A148: The radiosensitizing effects of the novel brain penetrant and potent ATM inhibitor WSD0628 in glioblastoma and melanoma patient derived xenografts. Mol Cancer Ther (2023) 22 (12_Supplement): A148. |