Danshensu sodium

CAS: 81075-52-7 F: C9H9NaO5 W: 220.15

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition o

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Bioactivity	Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].
Invitro	Danshensu (Dan shen suan A) sodium 有效抑制 SARS-CoV-2 S 蛋白假型病毒 (SARS-CoV-2 S) 进入 ACE2 过表达的 HEK-293T 细胞 (IC50=0.31μM) 和 Vero-E6 细胞 (IC50=4.97μM)[1]. Danshensu (0-100 μM；24小时) sodium 在较高浓度 (50 和 100 μM) 会导致 FaDu 和 Ca9-22 细胞的迁移和侵袭显着减少[2]. Danshensu (0-100 μM；24小时) sodium 剂量依赖性降低 FaDu 细胞中 ERK 磷酸化和 p38 磷酸化[2]. Danshensu (0-100 μM；24、48、72 小时) sodium 对人口腔癌细胞没有任何细胞毒性作用[2]. 0 --> Danshensu sodium 相关抗体: Cell Migration Assay [2] Cell Line:
In Vivo	Danshensu (Dan shen suan A; 25、50、100mg/kg；每天口服给药，连续 7 天或静脉注射一次) sodium 在 SARS-CoV-2 S 感染前给药后，可剂量依赖性地减轻 SARS-CoV-2 S 感染小鼠的病理改变[1]. Animal Model:
Name	Danshensu sodium
CAS	81075-52-7
Formula	C9H9NaO5
Molar Mass	220.15
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43(4):771-780. [2]. V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436. [3]. Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995.