| Bioactivity | WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease[1]. |
| CAS | 2879251-26-8 |
| Formula | C21H27N3O4 |
| Molar Mass | 385.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kerrigan JR, et al. Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease. J Med Chem. 2024 Nov 28;67(22):20682-20694. |
WIZ degrader 8
CAS: 2879251-26-8 F: C21H27N3O4 W: 385.46
WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently indu
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