| Bioactivity | PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with the IC50 of 0.27 nM. PI3Kδ-IN-23 bounds to PI3Kδ by covalent-bonding interactions with Lys779. PI3Kδ-IN-23 plays an important role in cancer research[1]. |
| CAS | 3051828-81-7 |
| Formula | C30H30N6O5 |
| Molar Mass | 554.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bo Yuan, et al. Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation. J Med Chem. 2024 Nov 28;67(22):20076-20099. |