| Bioactivity | W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway[1]. |
| Invitro | W1131（0-2 μM；72 h）抑制胃癌 AGS 细胞的存活、迁移和侵袭，并在处理 3 天后，抑制集落形成[1]。W1131（0.1-3 μM；24 小时）有效抑制 AGS 细胞中 STAT3 的磷酸化[1]。W1131（1 μM；48 小时）触发铁死亡并抑制胃癌中 GPX4、SLC7A11 和 FTH1 的表达[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | W1131（3 mg/kg，10 mg/kg；腹腔注射；每天一次，持续 2 周）以剂量依赖性方式抑制肿瘤生长，并在 BALB/c-nu/nu 小鼠的 MGC803 皮下异种移植模型中诱导铁死亡[1] 。 Animal Model: |
| Name | W1131 |
| CAS | 2740522-79-4 |
| Formula | C23H19N5O4 |
| Molar Mass | 429.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ouyang S, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 2022 Jun;52:102317. |