| Bioactivity | Maysin, a neuroprotective C-glycosyl-flavone, can be isolated from corn silk. Maysinshows protective activity against the damage caused by Syn amyloid aggregates-oligomers and fibrils. Maysinprevents oxidative stress and imbalance of intracellular calcium homeostasis, activating an autophagic degradative process. Maysincan be used for research of Parkinson's disease (PD)[1]. |
| Invitro | Maysin (2.5-15 μM；24 小时) 在 2.5 μM 和 5 μM 时对 SH-SY5Y 细胞显示出不显着的细胞毒性[1]。Maysin (2.5-15 μM；4 小时) 在 SH-SY5Y 细胞中通过自噬激活防止 Syn 寡聚体的细胞毒性[1]。 |
| In Vivo | Maysin (100 mg/kg 玉米须提取物，高 Maysin 含量；口服；每天一次，持续 4 周) 对大鼠没有毒性[2]。Maysin (100 mg/kg 玉米须提取物；口服；每天一次，持续 4 周) 抑制 5α-R2 和 PCNA 的 mRNA 表达，降低 5α-R2、DHT 和 PSA 的浓度，改善良性前列腺增生 (BPH) 大鼠模型[2]。 |
| Name | Maysin |
| CAS | 70255-49-1 |
| Formula | C27H28O14 |
| Molar Mass | 576.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Leri M, et al. Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation. Food Chem Toxicol. 2020 Oct;144:111626. [2]. Kim SR, et al. Corn silk extract improves benign prostatic hyperplasia in experimental rat model. Nutr Res Pract. 2017 Oct;11(5):373-380. |