| Bioactivity | W-2429 (NSC294836) is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats[2]. |
| In Vivo | W-2429 is a non-narcotic analgesic agent. Treatment with W-2429 is well tolerated by rats as well as dogs. In the dog, the only signs of toxicity observed are decreased appetite and salivation at 100 mg/kg/day W-2429. No other significant evidence of physical, chemical, gross or histopathologic change is observed[1]. |
| Name | W-2429 |
| CAS | 37795-69-0 |
| Formula | C10H8N2O2 |
| Molar Mass | 188.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Banerjee BN, et al. Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acuteand subacute toxicity in mice, rats and dogs. Arzneimittelforschung. 1977;27(4):793-801. [2]. Reisner DB, Ludwig BJ, Simon E, Dejneka T, Sofia RD. 2,3-Dihydro-9H-isoxazolo[3,2-b]quinazolin-9-ones and 3,4-dihydro-(1,2)-oxazino [3,2-b]quinazolin-10(2H)-ones. Arzneimittelforschung. 1977;27(4):766-770. |