BACE1-IN-1_product_DataBase

CAS: 1310347-50-2 F: C18H14F3N5O2 W: 389.33

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2,

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

Target

IC50: 32 nM (human BACE1), 47 nM (human BACE2)

Name

BACE1-IN-1

CAS

1310347-50-2

Formula

C18H14F3N5O2

Molar Mass

389.33

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95.

PeptideDB

BACE1-IN-1

CAS: 1310347-50-2 F: C18H14F3N5O2 W: 389.33