| Bioactivity | BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively. | ||||||||||||
| Target | IC50: 32 nM (human BACE1), 47 nM (human BACE2) | ||||||||||||
| Name | BACE1-IN-1 | ||||||||||||
| CAS | 1310347-50-2 | ||||||||||||
| Formula | C18H14F3N5O2 | ||||||||||||
| Molar Mass | 389.33 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. |
BACE1-IN-1
CAS: 1310347-50-2 F: C18H14F3N5O2 W: 389.33
BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2,
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