| Bioactivity | Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses infection with IC90 values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection. Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells[1]. |
| Target | IC50: 6.4 μM (H1N1) and 5.0 μM (H1N1) |
| Invitro | Viral polymerase-IN-1 hydrochloride (化合物 2h; 0.1, 1, 10 μM; 过夜) 以剂量依赖性方式降低病毒 NP 蛋白表达和病毒 RNA 拷贝[1]。 Viral polymerase-IN-1 hydrochloride (11, 33, 100 μM; 72 小时) 以剂量依赖的方式有效抑制病毒聚合酶活性，从而抑制人细胞 HeLa 中甲型流感病毒 PR8 的聚合酶活性[1]。 Viral polymerase-IN-1 hydrochloride 有效抑制 SARS-CoV-2 感染，在 Calu-3 细胞中 EC50 值为 0.46 μM，CC50 值高于 100 μM，SI 值>217.4[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | Viral polymerase-IN-1 hydrochloride (化合物 2h; 5 mg/kg; 腹腔给药; 每天一次; 持续 5 天; 在病毒感染前 4 小时开始) 不仅可以降低小鼠肺部的病毒 RNA 水平，还可以减轻感染介导的肺部浸润[1]。 Animal Model: |
| Name | Viral polymerase-IN-1 hydrochloride |
| CAS | 2367587-02-6 |
| Formula | C15H16ClF2N5O5 |
| Molar Mass | 419.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hyeon-Min Cha, et al. Evaluation of Antiviral Activity of Gemcitabine Derivatives against Influenza Virus and Severe Acute Respiratory Syndrome Coronavirus 2. ACS Infect Dis. 2023 Apr 14;9(4):1033-1045. |
Viral polymerase-IN-1 hydrochloride
CAS: 2367587-02-6 F: C15H16ClF2N5O5 W: 419.77
Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses in
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