Tyrosinase-IN-11_product_DataBase

Bioactivity	Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1].
Invitro	Tyrosinase-IN-11 (化合物 11c; 0.1-2 μM; 72 小时) 以剂量依赖性方式降低 TYR 和 MiTF 的蛋白质水平[1]。 Tyrosinase-IN-11 (50 μM) 对人恶性黑色素瘤细胞 A375 和 B16F10 细胞具有轻微的细胞毒性[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	Tyrosinase-IN-11 (化合物 11c; 0.5, 1 mM; 局部给药; 每天在紫外线照射前，持续 2 周; 或在连续两周暴露于紫外线灯下，5 天/周，持续 2 周) 在豚鼠体内表现出强大的抗黑色素生成能力[1]。 Animal Model:
Name	Tyrosinase-IN-11
CAS	240797-64-2
Formula	C15H14O5
Molar Mass	274.27
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Songtao Xue, et al. Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation. J Med Chem. 2023 Apr 13;66(7):5099-5117.

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