| Bioactivity | Vem-L-Cy5 (compound 3)，modified with the NIR fluorophore cyanine-5 (Cy5)，is a Vemurafenib (HY-12057)-based inhibitor of BRAF. Vem-L-Cy5 targets to BRAFV600E，and also inhibits MEK phosphorylation. Vem-L-Cy5 has cell permeability，and inhibits cell growth of many types of cancer[1]. |
| Name | Vem-L-Cy5 |
| Formula | C63H68F5N7O9S |
| Molar Mass | 1194.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Barresi E, et al. A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells. Eur J Med Chem. 2023 Aug 5;256:115446. |