| Bioactivity | VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule [1]. |
| Invitro | VU661 (1, 3, 10 μM; 0-144 小时) 以剂量依赖的方式产生周期延长效应 (10 μM 时为 7.2 小时)，并且对 Bmal1-dLuc U2OS 细胞系的振幅影响最小[1]。 VU661 (1, 10 μM; 24小时) 在细胞中以剂量依赖性方式增加光学氧化还原比[1]。 VU661 对细胞 ROS 或过氧化氢水平几乎没有影响[1]。 |
| Name | VU661 |
| CAS | 37648-76-3 |
| Formula | C19H13N3O |
| Molar Mass | 299.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kevin P Kelly, et al. Screen for Small-Molecule Modulators of Circadian Rhythms Reveals Phenazine as a Redox-State Modifying Clockwork Tuner. ACS Chem Biol. 2022 Jul 15;17(7):1658-1664. |