| Bioactivity | VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM[1]. | ||||||||||||
| Invitro | VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes[1]. | ||||||||||||
| In Vivo | VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice[1]. Animal Model: | ||||||||||||
| Name | VU6012962 | ||||||||||||
| CAS | 2313526-86-0 | ||||||||||||
| Formula | C21H19F3N4O4 | ||||||||||||
| Molar Mass | 448.40 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Reed CW, et al. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 NegativeAllosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzami |
VU6012962
CAS: 2313526-86-0 F: C21H19F3N4O4 W: 448.40
VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (m
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