| Bioactivity | LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1]. | ||||||||||||
| Target | mHTT-LC3 Linker Compound | ||||||||||||
| Invitro | LC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons[1]. | ||||||||||||
| Name | LC3-mHTT-IN-AN1 | ||||||||||||
| CAS | 486443-73-6 | ||||||||||||
| Formula | C15H9Br2NO3 | ||||||||||||
| Molar Mass | 411.04 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. |
LC3-mHTT-IN-AN1
CAS: 486443-73-6 F: C15H9Br2NO3 W: 411.04
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT)
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