| Bioactivity | VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia[1]. |
| In Vivo | VU6004256 (10 mg/kg; i.p.) 减弱 NR1 KD 小鼠前额皮质中过度的锥体细胞放电[1]。VU6004256 (3, 10 mg/kg; i.p.) 逆转 NR1 KD 小鼠新物体识别和提示介导的恐惧条件反射任务中的表现障碍并减少过度运动活动[1]。 Animal Model: |
| Name | VU6004256 |
| CAS | 2011034-33-4 |
| Formula | C25H25F2N5O2 |
| Molar Mass | 465.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Grannan MD, et al. Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716. |
VU6004256
CAS: 2011034-33-4 F: C25H25F2N5O2 W: 465.50
VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU60
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