| Bioactivity | MDT-637 (VP 14637) is a novel respiratory syncytial virus (RSV) fusion inhibitor with an IC50 of 1.42 ng/mL. |
| Target | IC50: 1.42 ng/mL (RSV) |
| Invitro | MDT‐637 has broad in vitro antiviral activity on clinical strains of different RSV genotypes and clades. MDT-637 inhibits three laboratory strains (RSV-A Long, RSV-A2, and RSV-9320) and four clinical strains (RSV-Memphis-37, RSV-LAP0824, and RSV-HAN1135) with IC50s range from 0.36 to 3.4 ng/mL[1]. 0 --> VP-14637 相关抗体: |
| Name | VP-14637 |
| CAS | 235106-62-4 |
| Formula | C25H22N10O3 |
| Molar Mass | 510.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim YI, et al. The antiviral effects of RSV fusion inhibitor, MDT-637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin. Influenza Other Respir Viruses. 2017 Nov;11(6):525-530. |