| Bioactivity | VII-31 is a potent NEDDylation pathway activator to inhibit the tumor progression in vitro and in vivo. VII-31 induces apoptosis via intrinsic and extrinsic pathways[1]. | ||||||||||||
| Invitro | VII-31 (100 nM, 200 nM; 48 hours) inhibits the cell viability of gastric cell line MGC803 with an IC50 of 0.09±0.01 μM. VII-31 also inhibits the cell viability of MCF-7 and PC-3 with IC50s of 0.10±0.006 and 1.15±0.28μM , respectively[1].VII-31 (50-150 nM; 24 hours) arrests MGC803 cells cycle in G2/M phase[1].VII-31 (50-150 nM; 48 hours) induces apoptosis via intrinsic and extrinsic pathways[1].VII-31 (50-150 nM; 24 hours) activates NEDDylation in MGC803 cells[1].VII-31 (50-150 nM; 48 hours) up-regulates pro-apoptotic proteins FADD, Fasl, PIDD, Bax, Bad; while down-regulates anti-apoptotic proteins Bcl-xL, Bcl-2, XIAP, c-IAP1[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | VII-31 | ||||||||||||
| CAS | 2305757-96-2 | ||||||||||||
| Formula | C23H25NO5S | ||||||||||||
| Molar Mass | 427.51 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|