| Bioactivity | VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s of 0.29 and 0.35 μM, respectively. VEGFR-IN-3 can be used for the research of cancer[1]. |
| Invitro | VEGFR-IN-3 (10 μM; 60 min) inhibits a variety of cancer cell lines growth[1].VEGFR-IN-3 (0-100 μM; 72 h) shows cytotoxic activities against MDA-MB-468 and OVCAR-4 cancer cell lines[1].VEGFR-IN-3 (0.29-0.35 μM; 2.5 h) decreases the concentration of VEGF in OVCAR-4 and MDA-MB-468 cell lines[1].VEGFR-IN-3 (0.29 μM; 48 h) increases levels of ERK1 and ERK2, activates ERK1 and ERK2 phosphorylation[1].VEGFR-IN-3 (0.29 μM; 24 h) affects cell cycle and induces apoptosis of OVCAR-4 cancer cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | VEGFR-IN-3 |
| CAS | 2874264-13-6 |
| Formula | C27H28N2O6 |
| Molar Mass | 476.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
VEGFR-IN-3
CAS: 2874264-13-6 F: C27H28N2O6 W: 476.52
VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s
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