| Bioactivity | Chol-CTPP is a ligand with dual targeting effect on blood-brain barrier (BBB) and glioma cells. Lip-CTPP can be gained by Chol-CTPP and another mitochondria targeting ligand (Chol-TPP). Lip-CTPP is a promising potential carrier to exert the anti-glioma effect of doxorubicin (DOX) and lonidamine (LND) collaboratively. Lip-CTPP elevates the inhibition rate of tumor cell proliferation, migration and invasion, promote apoptosis and necrosis, and interfere with mitochondrial function[1]. |
| Invitro | Lip-CTPP shows satisfying cellular uptake and mitochondrial uptake[1].Lip-CTPP (0-20 µg/mL DOX and LND, 24 h) shows cytotoxicity and induces apoptosis in C6 cells[1].Lip-CTPP inhibits intracellular ATP production and has the most severe damage on the membrane potential of mitochondria[1].Lip-CTPP possesses excellent potential to induce ROS generation[1].Lip-CTPP (0.5 µg/mL DOX, 48 h) exhibits strong inhibitory effect both on cell migration and invasion[1] Cell Cytotoxicity Assay[1] Cell Line: |
| Name | Chol-CTPP |
| Formula | C144H263N3O53 |
| Molar Mass | 2884.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |