| Bioactivity | VEGFR-2-IN-47 (compound 7g) is a potent VEGFR-2 inhibitor with an IC50 value of 0.072 µM. VEGFR-2-IN-47 demonstrates antiproliferative effects on MCF-7 and HepG2 cancer cells with IC50 values of 19.35 and 27.89 µM, respectively. VEGFR-2-IN-47 can induce G2 / M phase cell cycle arrest, promote apoptosis, and boost immunomodulation by downregulating TNF-α expression and upregulating IL-2 levels in MCF-7 cells. VEGFR-2-IN-47 has the potential to be used for the research of cancer such as breast cancer and liver carcinoma [1]. |
| Invitro | VEGFR-2-IN-47 (compound 7g) (48 h) exhibits highly selective antiproliferative activity against MCF-7 and HepG2 cancer cells with IC50s values of 19.35 and 27.89 µM, respectively. VEGFR-2-IN-47 displays low toxicity to a normal cell line (WI38) , indicating a favorable safety profile[1].VEGFR-2-IN-47 (19.35 μM; 72 h) can induce apoptosis in MCF-7 cells and arrest them in the G2 / M phase[1].VEGFR-2-IN-47 (19.35 μM) can promote apoptosis by downregulating Bcl-2 expression and upregulating Bax levels, and boost immunomodulation by downregulating TNF-α expression and upregulating IL-2 levels in MCF-7 cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VEGFR-2-IN-47 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Formula | C23H22N6O4 |
| Molar Mass | 446.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jingyi Liu, et al. Identification of 3-(9H-carbazol-9-yl)-2-(1,3-dioxoisoindolin-2-yl)propanoic acids as promising DNMT1 inhibitors. Eur J Med Chem. 2024 Aug 5;274:116538. |