| Bioactivity | Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2]. | ||||||||||||
| Invitro | Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2]. | ||||||||||||
| Name | Uric acid | ||||||||||||
| CAS | 69-93-2 | ||||||||||||
| Formula | C5H4N4O3 | ||||||||||||
| Molar Mass | 168.11 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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