UT-B-IN-1_product_DataBase

Bioactivity	UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1].
Target	IC50: 10 nM (human UT-B); 25 nM (mouse UT-B)
Invitro	UT-B-IN-1 (1-1000 nM) 抑制尿素预载红细胞的尿素外排，IC50 值为 26.7 nM[1]。UT-B-IN-1 抑制 AQP1-null 红细胞的水运输[1]。UT-B-IN-1 (0-10 μM；24 h) 对 MDCK 细胞无细胞毒性[1]。 Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	UT-B-IN-1 (300 μg；腹腔注射，1 次) 在自由取水和进食的小鼠中，增加排尿量并降低尿液渗透性[1]。 Animal Model:
Name	UT-B-IN-1
CAS	892742-76-6
Formula	C20H17N5O2S3
Molar Mass	455.58
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20.

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