| Bioactivity | (R)-V-0219 is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R)-V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R[1]. |
| Invitro | (R)-V-0219 (0.1 nM) 能够激活稳定表达 hGLP-1R 的 HEK 细胞中的钙流，并诱导 GLP-1 刺激的受体激活，EC50 值为 10 nM[1]。 |
| Name | (R)-V-0219 |
| Formula | C20H25F3N4O2 |
| Molar Mass | 410.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461. |