| Bioactivity | UNC9036 is a PROTAC-based STING degrader, with a DC50 of 227 nM. UNC9036-mediated STING degradation is proteasome and VHL dependent (Srtucture Note: Red, STING agonist diABZI (HY-112921A); Blue, VHL ligand VH032 (HY-120217); Black, linker)[1]. |
| Invitro | UNC9036 介导的降解通过多步骤机制发生：1: diABZI PROTAC结合并激活STING，激活的STING被磷酸化；2: VHL配体招募VHL靶向磷酸化的 STING 进行蛋白酶体降解。在UNC9036处理条件下，VHL耗尽部分挽救了STING表达[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> UNC9036 相关抗体: Western Blot Analysis[1]. Cell Line: |
| Formula | C73H95N17O11S |
| Molar Mass | 1418.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhichuan Zhu, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cell Mol Life Sci. 2023 May 14;80(6):149. |