| Bioactivity | UM171 is a selective agonist of human hematopoietic stem cell self-renewal. UM171 binds to hematopoietic cytokines and has the ability to promote the maintenance and expansion of human primary HSCs in vitro. UM171 can be used in the study of hematopoietic derivation of human pluripotent stem cells in vitro. | ||||||||||||
| Invitro | UM171 (50-100 nM) significantly increases CD34+ CD43+ and CD34+ CD45+ hematopoietic progenitors. UM171 enhances the derivation of hematopoietic cells at multiple developmental steps. UM171 enhances de novo generation of hematopoietic progenitor cells from hPSCs at multiple phases during hematopoietic differentiation in vitro. UM171 shows no effect on erythroid development, but inhibits erythroid maturation[1]. UM171 treatment enhances the engraftment potential of CD34+ macaque cells by threefold. UM171 attenuates cell differentiation and promotes ex vivo expansion of primitive human hematopoietic cells, and promotes expansion of LT-HSCs. UM171 treatment results in down-regulation of AhR target genes such as CYP1B1, CYP1A1, and AhRR[2]. 0 --> UM171 相关抗体: | ||||||||||||
| Name | UM171 | ||||||||||||
| CAS | 1448724-09-1 | ||||||||||||
| Formula | C25H27N9 | ||||||||||||
| Molar Mass | 453.54 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Li X, et al. Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Res. 2017 May;21:32-39. [2]. Fares I, et al. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science. 2014 Sep 19;345(6203):1509-12. |