| Bioactivity | Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. Piperazine erastin can be used in cancer research[1]. | ||||||||||||
| Invitro | Erastin is a ferroptosis activator. It triggers a unique iron-dependent form of non-apoptotic cell death that is termed as ferroptosis. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable. Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds[1]. 0 --> Piperazine Erastin 相关抗体: | ||||||||||||
| In Vivo | In the xenograft mouse model, a significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group. Ptgs2 is upregulated in mouse liver with 10 or 60 mg/kg piperazine erastin administration[1]. | ||||||||||||
| Name | Piperazine Erastin | ||||||||||||
| CAS | 1538593-71-3 | ||||||||||||
| Formula | C35H41ClN6O4 | ||||||||||||
| Molar Mass | 645.19 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Yang WS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1-2):317-331. |
Piperazine Erastin
CAS: 1538593-71-3 F: C35H41ClN6O4 W: 645.19
Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferr
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