| Bioactivity | UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with Ki of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research[1]. |
| Target | Ki: 0.20 µM (huPA); 2.79 µM (muPA) |
| Sequence | Ala-Cys-Asn-Ser-Lys-Phe-Ser-Gly-Cys-Gly-Val-Asp-Pro-Ser-Ser-Cys-Gly (cyclized via TBMB and Cys2,9,16) |
| Shortening | ACNSKFSGCGVDPSSCG (cyclized via TBMB and Cys2,9,16) |
| Formula | C72H105N19O25S3 |
| Molar Mass | 1732.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mazzocato Y, et al., A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue. Bioorg Med Chem. 2023 Nov 15;95:117499. |