| Bioactivity | MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a Ki value of 0.015 μM and aKd value of 0.036 μM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells[1]. | ||||||
| Invitro | MAIT-203 (10 μM and 25 μM; for 24 h) acetate 在 HEK293T 细胞中以剂量依赖性方式降低 Asef-APC 相互作用[1]。MAIT-203 (10 μM) acetate 显著减弱 SW480 和 HCT116 细胞迁移[1]。将 SW480 细胞与 MAIT-203（25、50 μM；24 小时）acetate 一起孵育，会导致 CDC42 活性形式的量出现剂量依赖性下降，但 Rac1 不会出现这种情况[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MAIT-203 acetate 相关抗体: | ||||||
| Sequence | Cbz-Ala-Gly-Glu-Ala-{S-3cyclopentylalamine}-Tyr-Glu-Gly-Gly-Gly-Gly-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2 | ||||||
| Shortening | Z-AGEA-{S-3cyclopentylalamine}-YEGGGGGRKKRRQRRR-NH2 | ||||||
| Formula | C108H121N43O31 | ||||||
| Molar Mass | 2517.85 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Haiming Jiang, et al. Peptidomimetic Inhibitors of APC-Asef Interaction Block Colorectal Cancer Migration. Nat Chem Biol. 2017 Sep;13(9):994-1001. |
MAIT-203 acetate
CAS: F: C108H121N43O31 W: 2517.85 (free base)
MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposi
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