| Bioactivity | UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs)[1]. |
| Invitro | UC-857993 (0-80 μM; 3 d) 特异性抑制野生型小鼠胚胎成纤维细胞的生长，但不抑制表达致癌 H-Ras(G12V) 的小鼠胚胎成纤维细胞的生长[1]。UC-857993 (60 μM, 80 μM; 2 h) 通过 EGFR-SOS1-Ras-Raf1-MEK-ERK 信号通路，剂量依赖地抑制的 Ras 激活和下游 ERK 激活[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | UC-857993 |
| CAS | 487001-04-7 |
| Formula | C25H22ClNO2 |
| Molar Mass | 403.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290(20):12879-98. |