Almurtide

CAS: 61136-12-7 F: C18H30N4O11 W: 478.45

Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows

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Bioactivity	Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].
In Vivo	Almurtide (80 mg/kg; 每天 1 次, 连续 4 天; 腹腔注射，静脉注射或皮下注射) 非特异性刺激巨噬细胞，对单核增生李斯特菌有抗感染活性。同时，它缺少口服活性，和庆大霉素 (HY-A0276A) 之间存在协同作用[2]。Almurtide (100 μg/mouse; 皮下注射; 2-3 个月 1 次, 共 2 次) 防止低剂量 Friend 白血病病毒引起的 SJL/J 小鼠的红白血病，延缓 RIII/Imr 小鼠自发乳腺肿瘤的发生[3]。
Name	Almurtide
CAS	61136-12-7
Formula	C18H30N4O11
Molar Mass	478.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Díaz-Eufracio BI, et al. Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides. Mol Divers. 2018 May;22(2):259-267. [2]. Fraser-Smith E B, et al. Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice. Infection and immunity, 1981, 34(3): 676-683. [3]. Acevedo H F, et al. Prevention of oncogenic viral infections in mice with CGP 11637, a synthetic muramyl dipeptide analog[J]. Antimicrobial agents and chemotherapy, 1985, 28(5): 589-596.