| Bioactivity | Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC50 for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization[1]. |
| Target | 2.40 μM (Microtubule/Tubulin) |
| Name | Tubulin/NEDDylation-IN-1 |
| Formula | C25H32N2O5S2 |
| Molar Mass | 504.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fu DJ, et al. Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity. J Enzyme Inhib Med Chem. 2023 Dec;38(1):166-175. |
Tubulin/NEDDylation-IN-1
CAS: F: C25H32N2O5S2 W: 504.66
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC50 for tubul
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.