| Bioactivity | Tubulin inhibitor 31 is a potent tubulin inhibitor with an IC50 value of 4 µM. Tubulin inhibitor 31 shows anti-proliferative activity. Tubulin inhibitor 31 inhibits the HUVEC migration[1]. |
| Target | IC50: 4 µM (Tubulin) |
| Invitro | Tubulin inhibitor 31 (compound 4J) (0-100 µM; 72 h) 显示出抗增殖活性，对于 HUVEC、HIG-82 细胞的 IC50 值分别为 0.126、0.39 µM[1]。Tubulin inhibitor 31 (0.012, 0.063 µM; 10 h) 以剂量依赖性方式显着抑制 HUVEC 迁移[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | Tubulin inhibitor 31 |
| Formula | C22H19NO2 |
| Molar Mass | 329.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Prudhomme V, et al. Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA). Eur J Med Chem. 2022 Dec 15;244:114809. |