Tubulin inhibitor 30_product_DataBase

Bioactivity	Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis[1].
Target	IC50: 0.52 μM (Tubulin)
Invitro	Tubulin inhibitor 30 (Compound 15) (0-100 nM; 48 h) inhibits the viability of MCF-7, U-87 MG and OVCAR-3 cells[1].Tubulin inhibitor 30 is metabolically stable when incubated with human liver microsomes[1]. Cell Viability Assay[1] Cell Line:
In Vivo	Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe2+ accumulation in mice[1]. Animal Model:
Name	Tubulin inhibitor 30
CAS	2873383-67-4
Formula	C22H19N3O5
Molar Mass	405.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Puxeddu M, et al. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor. J Med Chem. 2022 Nov 17.

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