| Bioactivity | FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1]. |
| Invitro | FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1]. |
| Name | FUBP1-IN-2 |
| CAS | 1242862-71-0 |
| Formula | C26H26ClN3O4 |
| Molar Mass | 479.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dobrovolskaite A, et al. Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function. J Med Chem. 2022 Nov 24;65(22):15391-15415. |
FUBP1-IN-2
CAS: 1242862-71-0 F: C26H26ClN3O4 W: 479.96
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-
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