| Bioactivity | Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α[1][2]. | ||||||||||||
| Invitro | Tryptanthrin (0-60 μM; 24, 48 and 72 h) inhibits the proliferation and colony formation of MCF-7 cells[1].Tryptanthrin (6.25-25 μM; 48 h; MCF-7 cells) reverses EMT-associated E-cadherin, MMP-2 and Snail[1].Tryptanthrin (0-30 μM; 15 min; MCF-7 cells) reduces Leukotriene (LT)-formation in human neutrophils with an IC50 value of 0.6 µM[2]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Tryptanthrin | ||||||||||||
| CAS | 13220-57-0 | ||||||||||||
| Formula | C15H8N2O2 | ||||||||||||
| Molar Mass | 248.24 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Tryptanthrin
CAS: 13220-57-0 F: C15H8N2O2 W: 248.24
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants.Tryptanthrin is a potent and
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