| Bioactivity | TrkA-IN-6 (compound R48) is a hydrazone-like, selective inhibitor of tropomyosin kinase type A receptor kinase (TrkA). TrkA-IN-6 exhibited a higher cytotoxic effect on U87 GBM cells than Temozolomide (HY-17364), with an IC50 of 68.99 μM[1]. |
| Target | tropomyosin kinase receptor kinase type A (TrkA) |
| Name | TrkA-IN-6 |
| Formula | C16H13N3O5 |
| Molar Mass | 327.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Murugesan A et al. Design, synthesis and anticancer evaluation of novel arylhydrazones of active methylene compounds. Int J Biol Macromol. 2023 Nov 10;254(Pt 3):127909. |