| Bioactivity | PVD-06 is a selective PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold) and induces PTPN2 degradation in a ubiquitination- and proteasome-dependent manner. PVD-06 promotes T cell activation and amplifies IFN-γ-mediated cytotoxicity. PVD-06 has anticancer activity[1]. |
| Target | PTPN2 |
| Name | PVD-06 |
| Formula | C48H55F4N9O11S2 |
| Molar Mass | 1074.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu L et al. Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader. J Med Chem. 2023 Nov 23;66(22):15269-15287. |