Trigothysoid N_product_DataBase

Bioactivity	Trigothysoid N is a daphnane diterpenoid with anticancer activity. Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. Trigothysoid N also induce apoptosis, can be used for research of non-small cell lung cancer (NSCLC)[1].
Invitro	Trigothysoid N (5、15 和 45 μM；48 小时) 以剂量依赖性方式抑制肿瘤细胞生长[1]。Trigothysoid N (5、10 和 20 μM；48 小时) 诱导细胞凋亡并使细胞周期停滞在 G0/G1 期[1]。Trigothysoid N (5、10 和 20 μM；48 小时) 诱导 MMP 去极化，并增加细胞 ROS 的产生，从而刺激 A549 细胞凋亡[1]。Trigothysoid N 通过线粒体依赖性信号通路诱导细胞凋亡，并通过调节 FAK 信号通路抑制 A549 细胞转移[1]。 Apoptosis Analysis[1] Cell Line:
In Vivo	Trigothysoid N (0.025、0.05 和 0.1 μM; 4 h) 在转基因斑马鱼模型中显示出抗血管生成活性和抗 A549 肿瘤活性[1]。 Animal Model:
Name	Trigothysoid N
CAS	1501943-08-3
Formula	C44H58O13
Molar Mass	794.92
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Y, et al. Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria and the STAT3/FAK pathway[J]. Arabian Journal of Chemistry, 2023, 16(8): 104930.

PeptideDB