| Bioactivity | Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC50 value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability[1]. |
| Invitro | Topoisomerase IIα-IN-7 (Compound 53b) 对 MCF-7 癌细胞系、HepG2 癌细胞系和人胚胎肾衍生 HEK293 细胞具有细胞毒性，IC50 值分别为 0.15 µM、0.13 µM、2.1 µM[1]。 |
| Name | Topoisomerase IIα-IN-7 |
| Formula | C22H23Cl3N4O3 |
| Molar Mass | 497.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Skok Ž, et al. ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold. Eur J Med Chem. 2023 Jan 18;249:115116. |
Topoisomerase IIα-IN-7
CAS: F: C22H23Cl3N4O3 W: 497.80
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC50 value of 7.7 µM. Topoisomerase IIα-IN-7 ha
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