Mpro inhibitor N3_product_DataBase

Bioactivity	Mpro inhibitor N3 is a potent SARS-CoV-2 MPro inhibitor with an EC50 value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59[1][2][3].
Invitro	Mpro inhibitor N3 (0-100 µM) 具有抗病毒活性，对 SARS-CoV-2 的 EC50 值为 16.77 µM[1]。Mpro inhibitor N3 (0-50 µM; 14 h) 抑制病毒生长，对 HCoV-229E、FIPV 和 MHV-A59 的 IC50 值分别为 4、8.8、2.7 µM[2]。
In Vivo	Mpro inhibitor N3 (0-0.64 µM; 3, 6 h) 在鸡胚胎中表现出抗 IBV 的抗病毒活性[3]。 Animal Model:
Name	Mpro inhibitor N3
CAS	884650-98-0
Formula	C35H48N6O8
Molar Mass	680.79
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jin Z, et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 Jun;582(7811):289-293. [2]. Yang H, et al. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol. 2005 Oct;3(10):e324. [3]. Xue X, et al. Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J Virol. 2008 Mar;82(5):2515-27.

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