| Bioactivity | Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629)[1]. |
| Invitro | Topoisomerase IIα-IN-5 (化合物 6) (5 μM, 10 μM, 20 μM; 10 d) 抑制 DU145 细胞集落形成[1]。Topoisomerase IIα-IN-5 (1 μM 和 10 μM; 72 h) 显示对 DU145 细胞有抗增殖作用[1]。Topoisomerase IIα-IN-5 对 DU145、HCT15 和 T47D 细胞的细胞毒作用 IC50 分别为 0.13 μM、9.25μM 和 0.53 μM[1]。Topoisomerase IIα-IN-5 (200 μM) 与 DNA 双螺旋结构相互作用[1]。Topoisomerase IIα-IN-5 (20 μM; 24 h) 诱导 CRPC 细胞 G2 周期阻滞和凋亡[1]。 Western Blot Analysis[1] Cell Line: |
| Name | Topoisomerase IIα-IN-5 |
| Formula | C25H30N2O5 |
| Molar Mass | 438.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |