| Bioactivity | Topoisomerase I/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II that leads to DNA damage and PARP-1 activation, followed by the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II inhibitor 8 exhibits significant anticancer activity, effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer[1]. |
| CAS | 355400-87-2 |
| Formula | C14H11Br2NO5S2 |
| Molar Mass | 497.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiong K, et al. Necroptosis induced by ruthenium (II) complexes as dual catalytic inhibitors of topoisomerase I/II[J]. Angewandte Chemie International Edition, 2020, 59(38): 16631-16637. |
Topoisomerase I/II inhibitor 8
CAS: 355400-87-2 F: C14H11Br2NO5S2 W: 497.18
Topoisomerase I/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II that leads to DNA dama
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