| Bioactivity | Tolindate is a potent PXR agonist with an EC50 value of 8.3 µM. Tolindate shows antifungal activity[1][2]. |
| Invitro | Tolindate (0-100 µM; 24 h) with the presence of SPA70 (0.5, 7.5 µM) shows significantly induces CYP3A4 in hPXR HepG2 cells[1]. |
| Name | Tolindate |
| CAS | 27877-51-6 |
| Formula | C18H19NOS |
| Molar Mass | 297.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lynch C, et al. Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library. Biochem Pharmacol. 2021 Feb;184:114368. [2]. Pastor L, et al. New antifungals selected by molecular topology. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2577-82. |