| Bioactivity | Tkip is a JAK2 specific inhibitor. Tkip can bind the JAK2 autophosphorylation site, inhibit the JAK2 autophosphorylation and the phosphorylation of the f IFN-γ receptor subunit IFNGR-1. Tkip inhibits the antiviral activity of IFN-γ and the expression of MHC Class I molecules. Tkip can be used to study the IFN-γ signaling pathway[1]. |
| CAS | 716361-65-8 |
| Sequence | Trp-Leu-Val-Phe-Phe-Val-Ile-Phe-Tyr-Phe-Phe-Arg |
| Shortening | WLVFFVIFYFFR |
| Formula | C93H118N16O14 |
| Molar Mass | 1684.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Flowers LO, et al. Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function. J Immunol. 2004 Jun 15;172(12):7510-8. |