| Bioactivity | LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with Kd value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8+ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer[1]. |
| Sequence | Cys-Val-Pro-Met-Thr-Tyr-Arg-Ala-Cys (disulfide bridge: Cys1-Cys9) |
| Shortening | CVPMTYRAC (disulfide bridge: Cys1-Cys9) |
| Formula | C43H68N12O12S3 |
| Molar Mass | 1041.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhai W, et al. A novel cyclic peptide targeting LAG-3 for cancer immunotherapy by activating antigen-specific CD8+ T cell responses. Acta Pharm Sin B. 2020 Jun;10(6):1047-1060. |
LAG-3 cyclic peptide inhibitor C25
CAS: F: C43H68N12O12S3 W: 1041.27
LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with hum
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